Stress, cortisol and memory as markers of serotonergic vulnerability
Article first published online: 19 SEP 2002
Volume 14, Issue 4, pages 186–191, August 2002
How to Cite
Riedel, W. J., Sobczak, S., Nicolson, N. and Honig, A. (2002), Stress, cortisol and memory as markers of serotonergic vulnerability. Acta Neuropsychiatrica, 14: 186–191. doi: 10.1034/j.1601-5215.2002.140405.x
- Issue published online: 19 SEP 2002
- Article first published online: 19 SEP 2002
- Accepted for publication ??????, 2002
- memory performance;
Objectives: In the present paper the association of stress-induced cortisol with memory impairment is discussed
Methods: An experiment is described in which an attempt is made to block stress-induced cortisol by lowering 5-HT neurotransmission by means of acute tryptophan depletion (ATD). Forty-five healthy control subjects participated in the experiment.
Results: Stress-induced peak cortisol and immediate memory performance were negatively associated. ATD tended to block stress-induced cortisol response. ATD also blocked the association between peak cortisol response and memory impairment.
Conclusions: Stress-induced cortisol and its association with memory impairment is mediated at least partially by serotonin.