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Viral vectors: from virology to transgene expression
Article first published online: 28 APR 2009
DOI: 10.1038/bjp.2008.349
© 2008 The Authors. Journal compilation © 2008 The British Pharmacological Society
Issue
British Journal of Pharmacology
Special Issue: Themed Section: Vector Design and Drug Delivery: Guest Editor: Kenneth Takeda
Volume 157, Issue 2, pages 153–165, May 2009
Additional Information
How to Cite
Bouard, D., Alazard-Dany, N. and Cosset, F.-L. (2009), Viral vectors: from virology to transgene expression. British Journal of Pharmacology, 157: 153–165. doi: 10.1038/bjp.2008.349
Publication History
- Issue published online: 28 APR 2009
- Article first published online: 28 APR 2009
- Received 14 April 2008; revised 9 July 2008; accepted 30 July 2008
- Abstract
- Article
- References
- Cited By
Keywords:
- viral vectors;
- gene therapy;
- AAV;
- Ad;
- HSV;
- lentivectors;
- pseudotyping;
- cell targeting;
- transcriptional targeting;
- vectors production
In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.
This article is part of a themed section on Vector Design and Drug Delivery. For a list of all articles in this section see the end of this paper, or visit: http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009