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Function and dysfunction of the PI system in membrane trafficking
Article first published online: 11 SEP 2008
Copyright © 2008 European Molecular Biology Organization
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The EMBO Journal
Volume 27, Issue 19, pages 2457–2470, October 8, 2008
How to Cite
Vicinanza, M., D'Angelo, G., Di Campli, A. and De Matteis, M. A. (2008), Function and dysfunction of the PI system in membrane trafficking. The EMBO Journal, 27: 2457–2470. doi: 10.1038/emboj.2008.169
- Issue published online: 8 OCT 2008
- Article first published online: 11 SEP 2008
- Manuscript Accepted: 5 AUG 2008
- Manuscript Received: 13 JUN 2008
- genetic diseases;
- membrane trafficking;
The phosphoinositides (PIs) function as efficient and finely tuned switches that control the assembly–disassembly cycles of complex molecular machineries with key roles in membrane trafficking. This important role of the PIs is mainly due to their versatile nature, which is in turn determined by their fast metabolic interconversions. PIs can be tightly regulated both spatially and temporally through the many PI kinases (PIKs) and phosphatases that are distributed throughout the different intracellular compartments. In spite of the enormous progress made in the past 20 years towards the definition of the molecular details of PI–protein interactions and of the regulatory mechanisms of the individual PIKs and phosphatases, important issues concerning the general principles of the organisation of the PI system and the coordination of the different PI-metabolising enzymes remain to be addressed. The answers should come from applying a systems biology approach to the study of the PI system, through the integration of analyses of the protein interaction data of the PI enzymes and the PI targets with those of the ‘phenomes’ of the genetic diseases that involve these PI-metabolising enzymes.