New EMBO Member's Review
Transient receptor potential channels meet phosphoinositides
Article first published online: 16 OCT 2008
Copyright © 2008 European Molecular Biology Organization
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
The EMBO Journal
Volume 27, Issue 21, pages 2809–2816, November 5, 2008
How to Cite
Nilius, B., Owsianik, G. and Voets, T. (2008), Transient receptor potential channels meet phosphoinositides. The EMBO Journal, 27: 2809–2816. doi: 10.1038/emboj.2008.217
- Issue published online: 5 NOV 2008
- Article first published online: 16 OCT 2008
- Manuscript Accepted: 23 SEP 2008
- Manuscript Received: 25 AUG 2008
- ion channels;
- transient receptor potential channels
Transient receptor potential (TRP) cation channels are unique cellular sensors that are involved in multiple cellular functions, ranging from transduction of sensory signals to the regulation of Ca2+ and Mg2+ homoeostasis. Malfunctioning of TRP channels is now recognized as the cause of several hereditary and acquired human diseases. At the time of cloning of the first Drosophila TRP channel, a close connection between gating and phosphatidylinositol phosphates (PIPs) was already recognized. In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP—PIP interactions to human physiology and pathophysiology.