See Glossary for abbreviations used in this article.
Lamins in development, tissue maintenance and stress
Article first published online: 13 NOV 2012
Copyright © 2012 European Molecular Biology Organization
Volume 13, Issue 12, pages 1070–1078, December 2012
How to Cite
Zuela, N., Bar, D. Z. and Gruenbaum, Y. (2012), Lamins in development, tissue maintenance and stress. EMBO reports, 13: 1070–1078. doi: 10.1038/embor.2012.167
- Issue published online: 1 DEC 2012
- Article first published online: 13 NOV 2012
- Manuscript Accepted: 1 OCT 2012
- Manuscript Received: 5 JUL 2012
- nuclear envelope;
- nuclear lamina;
Lamins are nuclear intermediate filament proteins. They provide mechanical stability, organize chromatin and regulate transcription, replication, nuclear assembly and nuclear positioning. Recent studies provide new insights into the role of lamins in development, differentiation and tissue response to mechanical, reactive oxygen species and thermal stresses. These studies also propose the existence of separate filament networks for A- and B-type lamins and identify new roles for the different networks. Furthermore, they show changes in lamin composition in different cell types, propose explanations for the more than 14 distinct human diseases caused by lamin A and lamin C mutations and propose a role for lamin B1 in these diseases.