Microbial laboratory evolution in the era of genome-scale science
Version of Record online: 5 JUL 2011
Copyright © 2011 EMBO and Macmillan Publishers Limited
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Molecular Systems Biology
Volume 7, Issue 1, 2011
How to Cite
Conrad, T. M., Lewis, N. E. and Palsson, B. Ø. (2011), Microbial laboratory evolution in the era of genome-scale science. Molecular Systems Biology, 7: n/a. doi: 10.1038/msb.2011.42
- Issue online: 5 JUL 2011
- Version of Record online: 5 JUL 2011
- Manuscript Accepted: 12 MAY 2011
- Manuscript Received: 21 FEB 2011
- flux-balance analysis;
- metabolic engineering;
- regulatory hub
Laboratory evolution studies provide fundamental biological insight through direct observation of the evolution process. They not only enable testing of evolutionary theory and principles, but also have applications to metabolic engineering and human health. Genome-scale tools are revolutionizing studies of laboratory evolution by providing complete determination of the genetic basis of adaptation and the changes in the organism's gene expression state. Here, we review studies centered on four central themes of laboratory evolution studies: (1) the genetic basis of adaptation; (2) the importance of mutations to genes that encode regulatory hubs; (3) the view of adaptive evolution as an optimization process; and (4) the dynamics with which laboratory populations evolve.