Ligand-Gated Ion Channels
Published Online: 24 APR 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Millar, N. S. 2006. Ligand-Gated Ion Channels. eLS. .
- Published Online: 24 APR 2006
Ligand-gated ion channels (LGICs) form a diverse superfamily of cell-surface neurotransmitter receptors that mediate rapid cell–cell signalling. They are multisubunit transmembrane proteins in which 3–5 subunits are arranged around a central ion channel pore. In addition to their role as receptors for neurotransmitters, LGICs have been implicated in several neurological disorders and are important target sites for drug therapy and drug development.
- ion channels;
- neurotransmitter receptors;
- signal transduction