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Ligand-Gated Ion Channels

  1. Neil S Millar

Published Online: 24 APR 2006

DOI: 10.1038/npg.els.0000154

eLS

eLS

How to Cite

Millar, N. S. 2006. Ligand-Gated Ion Channels. eLS. .

Author Information

  1. University College London, London, UK

Publication History

  1. Published Online: 24 APR 2006

Abstract

Ligand-gated ion channels (LGICs) form a diverse superfamily of cell-surface neurotransmitter receptors that mediate rapid cell–cell signalling. They are multisubunit transmembrane proteins in which 3–5 subunits are arranged around a central ion channel pore. In addition to their role as receptors for neurotransmitters, LGICs have been implicated in several neurological disorders and are important target sites for drug therapy and drug development.

Keywords:

  • ion channels;
  • neurotransmitter receptors;
  • receptors;
  • signal transduction