Standard Article

GABAB Receptors

  1. Klemens Kaupmann,
  2. Wolfgang Froestl,
  3. Bernhard Bettler

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000234



How to Cite

Kaupmann, K., Froestl, W. and Bettler, B. 2001. GABAB Receptors. eLS. .

Author Information

  1. Novartis Pharma AG, Basel, Switzerland

Publication History

  1. Published Online: 19 APR 2001


γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/C) and metabotropic (GABAB) receptor systems. GABAB receptors modulate synaptic transmission and are structurally related to the metabotropic glutamate receptors. The properties of the recently cloned GABABR1a and -b receptors are compared to brain GABAB receptors.


  • baclofen;
  • expression cloning;
  • metabotropic;
  • mGluR;
  • G-protein;
  • epilepsy