Standard Article

Initiation Factors in Eukaryotes

  1. William C Merrick

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000545

eLS

eLS

How to Cite

Merrick, W. C. 2001. Initiation Factors in Eukaryotes. eLS. .

Author Information

  1. Case Western Reserve University, Cleveland, Ohio, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

Initiation factors are those proteins that facilitate the assembly of the initiator tRNA, mRNA and ribosomes into an initiation complex. This assembly correctly matches the AUG start codon of the mRNA with the anticodon of the initiator tRNA in the ribosomal P site and thereby determines the translational reading frame.

Keywords:

  • protein synthesis;
  • initiation factors;
  • scanning;
  • helicase;
  • ribosomes;
  • tRNA;
  • mRNA;
  • ATP;
  • GTP