DNA Mismatch Repair: Eukaryotic
Published Online: 25 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Hays, J. B. 2001. DNA Mismatch Repair: Eukaryotic. eLS. .
- Published Online: 25 APR 2001
In both prokaryotes and eukaryotes, highly-conserved mismatch-repair systems both correct DNA replication errors, by coupling recognition of DNA mismatches to identification and excision of the mutated nascent DNA, and interact with recombination mismatches and a variety of DNA lesions. Evolution of single prokaryotic recognition (MutS) and coupling (MutL) proteins into multiple specialized eukaryotic proteins has accompanied expansion of their genomic-stability functions.
- genomic stability;
- error correction;
- DNA replication;