Standard Article

DNA Mismatch Repair: Eukaryotic

  1. John Bruce Hays

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0000570

eLS

eLS

How to Cite

Hays, J. B. 2001. DNA Mismatch Repair: Eukaryotic. eLS. .

Author Information

  1. Oregon State University, Corvallis, Oregon, USA

Publication History

  1. Published Online: 25 APR 2001

Abstract

In both prokaryotes and eukaryotes, highly-conserved mismatch-repair systems both correct DNA replication errors, by coupling recognition of DNA mismatches to identification and excision of the mutated nascent DNA, and interact with recombination mismatches and a variety of DNA lesions. Evolution of single prokaryotic recognition (MutS) and coupling (MutL) proteins into multiple specialized eukaryotic proteins has accompanied expansion of their genomic-stability functions.

Keywords:

  • genomic stability;
  • error correction;
  • DNA replication;
  • mutagenesis;
  • meiosis