Human Mismatch Repair: Defects and Predisposition to Cancer
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Karran, P. 2001. Human Mismatch Repair: Defects and Predisposition to Cancer. eLS. .
- Published Online: 19 APR 2001
Mismatch repair edits DNA replication and reduces spontaneous mutation rates. Individuals with inherited mutations in a mismatch repair gene are susceptible to cancer, and the absence of mismatch repair renders their tumours resistant to some anticancer drugs.
- hereditary nonpolyposis colorectal cancer;
- mutator phenotype;
- microsatellite instability;
- DNA damage tolerance;
- alkylating agents;