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Human Mismatch Repair: Defects and Predisposition to Cancer

  1. Peter Karran

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000572

eLS

eLS

How to Cite

Karran, P. 2001. Human Mismatch Repair: Defects and Predisposition to Cancer. eLS. .

Author Information

  1. Imperial Cancer Research Fund, South Mimms, Hertfordshire, UK

Publication History

  1. Published Online: 19 APR 2001

Abstract

Mismatch repair edits DNA replication and reduces spontaneous mutation rates. Individuals with inherited mutations in a mismatch repair gene are susceptible to cancer, and the absence of mismatch repair renders their tumours resistant to some anticancer drugs.

Keywords:

  • hereditary nonpolyposis colorectal cancer;
  • mutator phenotype;
  • microsatellite instability;
  • DNA damage tolerance;
  • alkylating agents;
  • cisplatin