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Eukaryotic Recombination: Initiation by Double-strand Breaks

  1. Christine Richardson1,
  2. Maria Jasin2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000577

eLS

eLS

How to Cite

Richardson, C. and Jasin, M. 2001. Eukaryotic Recombination: Initiation by Double-strand Breaks. eLS. .

Author Information

  1. 1

    Sloan-Kettering Institute, New York, New York, USA

  2. 2

    Sloan-Kettering Institute, New York, New York, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

A double-strand break in one deoxyribonucleic acid (DNA) double helix, possibly caused by DNA damaging agents such as ionizing radiation or normal metabolic processes, stimulates repair by a pathway of recombination that uses a second unbroken DNA double helix containing homologous sequences as a donor of genetic information to restore the intact DNA structure.

Keywords:

  • DNA repair;
  • double-strand break;
  • genome stability;
  • recombination