Eukaryotic Recombination: Initiation by Double-strand Breaks
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Richardson, C. and Jasin, M. 2001. Eukaryotic Recombination: Initiation by Double-strand Breaks. eLS. .
- Published Online: 19 APR 2001
A double-strand break in one deoxyribonucleic acid (DNA) double helix, possibly caused by DNA damaging agents such as ionizing radiation or normal metabolic processes, stimulates repair by a pathway of recombination that uses a second unbroken DNA double helix containing homologous sequences as a donor of genetic information to restore the intact DNA structure.
- DNA repair;
- double-strand break;
- genome stability;