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Transition States: Substrate-induced Conformational Transitions

  1. Carol B Post

Published Online: 28 MAY 2003

DOI: 10.1038/npg.els.0000604

eLS

eLS

How to Cite

Post, C. B. 2003. Transition States: Substrate-induced Conformational Transitions. eLS. .

Author Information

  1. Purdue University, West Lafayette, Indiana, USA

Publication History

  1. Published Online: 28 MAY 2003

Abstract

Substrate binding produces a variety of conformational changes in an enzyme that result in favourable substrate–protein interactions and influence catalysis in different ways. The altered form of the enzyme often appears to be more active in catalysis. A specific conformational change that continues into the transition state complex is the basis for substrate specificity.

Keywords:

  • induced-fit mechanism;
  • transition state;
  • substrate specificity;
  • ground state destabilization;
  • entropy of activation;
  • concentrated protein motions;
  • conformational dynamics