Transition States: Substrate-induced Conformational Transitions
Published Online: 28 MAY 2003
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Post, C. B. 2003. Transition States: Substrate-induced Conformational Transitions. eLS. .
- Published Online: 28 MAY 2003
Substrate binding produces a variety of conformational changes in an enzyme that result in favourable substrate–protein interactions and influence catalysis in different ways. The altered form of the enzyme often appears to be more active in catalysis. A specific conformational change that continues into the transition state complex is the basis for substrate specificity.
- induced-fit mechanism;
- transition state;
- substrate specificity;
- ground state destabilization;
- entropy of activation;
- concentrated protein motions;
- conformational dynamics