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Binding and Catalysis

  1. Michael D Toney

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000629



How to Cite

Toney, M. D. 2001. Binding and Catalysis. eLS. .

Author Information

  1. University of California–Davis, California, USA

Publication History

  1. Published Online: 19 APR 2001


Binding and catalysis in the biological context are defined as the formation of a relatively long-lived and specific complex between a macromolecular catalyst and a substrate molecule, which subsequently undergoes a chemical transformation much faster than would occur in the absence of the macromolecular catalyst.


  • entropy loss;
  • induced fit;
  • stereoelectronic effects;
  • ground state destabilization;
  • transition state stabilization;
  • circe effect