Nitric Oxide: Synthesis and Action
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Wu, K. K. 2001. Nitric Oxide: Synthesis and Action. eLS. .
- Published Online: 19 APR 2001
Nitric oxide is an important mediator of diverse physiological functions such as vascular relaxation, neurotransmission and host defence. It is synthesized endogenously by the action of nitric oxide synthases and formed from organic nitrates and nitrites. Through its action on guanylyl cyclase it increases cellular levels of cyclic GMP, which accounts for most NO activities. Excessive NO production causes tissue damages through its direct actions on intracellular constituents and its formation of peroxynitrite with superoxide.
- nitric oxide;
- nitric oxide synthase;
- guanylyl cyclase;