Standard Article

Metabolic Turnover

  1. J Nielsen

Published Online: 25 JUL 2001

DOI: 10.1038/npg.els.0000635

eLS

eLS

How to Cite

Nielsen, J. 2001. Metabolic Turnover. eLS. .

Author Information

  1. Technical University of Denmark, Lyngby, Denmark

Publication History

  1. Published Online: 25 JUL 2001

Abstract

Metabolic turnover is the sum of all biochemical reactions – the metabolic network – within a living cell that are involved in the conversion of substrates, particularly carbon, nitrogen and energy sources into Gibbs free energy, secreted metabolites and cell mass. Analysis of metabolic turnover involves identification of which reactions are active in a cell, and of quantifying the fluxes carried by the branches of the network and elucidating how these fluxes are controlled. Control of fluxes takes place at many levels, but the usual distinction is between global and local control.

Keywords:

  • metabolic flux analysis;
  • metabolic control analysis;
  • biochemical pathways;
  • metabolism;
  • enzyme kinetics;
  • enzyme regulation