Standard Article

Enzymes: Coenzyme A dependent

  1. Peter M Shoolingin-Jordan,
  2. Matthew P Crump

Published Online: 21 AUG 2001

DOI: 10.1038/npg.els.0000640



How to Cite

Shoolingin-Jordan, P. M. and Crump, M. P. 2001. Enzymes: Coenzyme A dependent. eLS. .

Author Information

  1. University of Southampton, UK

Publication History

  1. Published Online: 21 AUG 2001


A large group of unrelated enzymes involved in primary and secondary metabolism utilize a thiol group to form acyl thiol esters. The enzymes form noncovalent interactions with the coenzyme A moiety and utilize the ketonic properties of the thiol ester to facilitate acyl transfer and nucleophilic activation.


  • coenzyme A (CoA)-dependent enzymes;
  • thiol ester;
  • C–C bond formation;
  • acyl group transfer