Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Mesters, J. R., Hogg, T. and Hilgenfeld, R. 2001. G Proteins. eLS. .
- Published Online: 19 APR 2001
The G proteins, or GTP-binding proteins, can be classified into three major groups: the large mammalian Gαβγ heterotrimers, the small Ras and Ras-like GTPases, and the intermediate-sized GTPases such as elongation factors Tu (EF1A) and G (EF2). All G proteins function as molecular switches controlled by a GTPase cycle, shuttling between an active GTP–Mg2+-bound form (the ‘on’ state) and an inactive GDP–Mg2+ complex (the ‘off’ state).
- heterotrimeric GTP-binding proteins;
- Ras-like proteins;
- elongation factors;
- molecular switch;
- signal transduction