Standard Article

Glycosaminoglycans: Structure and Biological Functions

  1. James D San Antonio1,
  2. Renato V Iozzo2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000704

eLS

eLS

How to Cite

Antonio, J. D. S. and Iozzo, R. V. 2001. Glycosaminoglycans: Structure and Biological Functions. eLS. .

Author Information

  1. 1

    Thomas Jefferson University, Philadelphia, Pennsylvania, USA

  2. 2

    Thomas Jefferson University, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

Glycosaminoglycans are among the most complex polysaccharide chains that are either covalently linked to protein cores (to form proteoglycans) or free as unsulfated hyaluronan. They exist associated with virtually all cell surfaces and extracellular matrices of higher organisms, where their fine structure facilitates interactions with proteins, which underlie their myriad biological functions.

Keywords:

  • glycosaminoglycans;
  • proteoglycans;
  • glycosaminoglycan-protein interactions;
  • mucopolysaccharidosis;
  • heparin