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Metalloenzymes and Electrophilic Catalysis

  1. Jason Eames,
  2. Michael Watkinson

Published Online: 3 MAY 2005

DOI: 10.1038/npg.els.0000724



How to Cite

Eames, J. and Watkinson, M. 2005. Metalloenzymes and Electrophilic Catalysis. eLS. .

Author Information

  1. Queen Mary, University of London, London, UK

Publication History

  1. Published Online: 3 MAY 2005


Enzymes perform a number of remarkable synthetic transformations at neutral pH and ambient temperatures. Many enzymes employ metal ions to aid in electrophilic catalysis. Zinc, the commonest Lewis acid in biochemistry, is an essential cofactor in over 300 enzymes.


  • general acid catalysis;
  • specific acid catalysis;
  • lewis acid catalysis;
  • non-redox metalloenzymes