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Molecular Biology: The Central Dogma

  1. Patricia J Pukkila

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000812



How to Cite

Pukkila, P. J. 2001. Molecular Biology: The Central Dogma. eLS. .

Author Information

  1. University of North Carolina at Chapel Hill, North Carolina, USA

Publication History

  1. Published Online: 19 APR 2001


Although proteins are essential components of all aspects of cell structure and function, they are not sufficient for their own propagation. Instead, the information necessary to specify each individual protein is stored in nucleic acids. The ‘central dogma’ of molecular biology states that sequence information can be transferred among nucleic acids, and from nucleic acids to proteins, but sequence information cannot be transferred among proteins, or from proteins to nucleic acids.


  • replication;
  • transcription;
  • translation;
  • reverse transcriptase;
  • adaptive mutation