Standard Article

Transmembrane Signalling

  1. Katalin A Holland1,
  2. I Barry Holland2

Published Online: 24 OCT 2002

DOI: 10.1038/npg.els.0000847



How to Cite

Holland, K. A. and Holland, I. B. 2002. Transmembrane Signalling. eLS. .

Author Information

  1. 1

    University of London, London, UK

  2. 2

    Université Paris-Sud, Orsey Cedex, France

Publication History

  1. Published Online: 24 OCT 2002


Surface protein receptors detect a wide variety of different external signal molecules, inducing a resulting change in the cytoplasmic domain of a receptor, which activates an associated response regulator to transcribe a specific gene. In this way, the cell responds appropriately and uniquely to specific signals.


  • receptor;
  • ligand;
  • response regulator;
  • second messenger;
  • kinase