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Repression Mechanism

  1. Sankar Adhya

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0000850



How to Cite

Adhya, S. 2001. Repression Mechanism. eLS. .

Author Information

  1. National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 25 APR 2001


Repressors are regulator proteins that inhibit transcription initiation at gene promoters in order to modulate gene expression in response to variations in environmental conditions. The molecular and biochemical mechanisms by which such repression is achieved vary widely, and are often modulated by signal molecules which act by altering their mechanism of action.


  • DNA looping;
  • contact inhibition;
  • dual regulator;
  • differential contact;
  • activator;
  • steric hindrance