Standard Article

DNA Looping and Transcription Regulation

  1. Dale EA Lewis,
  2. Sankar Adhya

Published Online: 12 DEC 2001

DOI: 10.1038/npg.els.0000851



How to Cite

Lewis, D. E. and Adhya, S. 2001. DNA Looping and Transcription Regulation. eLS. .

Author Information

  1. National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 12 DEC 2001


DNA loops, formed by the association of two proteins while bound to spatially separated specific DNA sites, control gene transcription negatively or positively. DNA looping sometimes needs an architectural protein, which acts by bending the DNA segment that loops.


  • enhancer;
  • repressor;
  • operator;
  • nucleoid;
  • GalR;
  • AraC;
  • NtrC;
  • repressosome