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Catalytic Antibodies

  1. Benoît Gigant1,
  2. Marcel Knossow2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000872

eLS

eLS

How to Cite

Gigant, B. and Knossow, M. 2001. Catalytic Antibodies. eLS. .

Author Information

  1. 1

    CNRS, Gif sur Yvette, France

  2. 2

    CNRS, Gif sur Yvette, France

Publication History

  1. Published Online: 19 APR 2001

Abstract

It is possible to elicit antibodies that catalyse a target reaction by raising them against stable molecules mimicking intermediate species on the chemical pathway from substrate to product. These artificial biocatalysts are closer to enzymes than any other enzyme mimic. Recent progress and new strategies bode well for the practical use of catalytic antibodies.

Keywords:

  • abzyme;
  • enzyme mimic;
  • transition state analogue;
  • antibody