Standard Article

Intron Homing

  1. David R Edgell,
  2. Markus Landthaler,
  3. David A Shub

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000883



How to Cite

Edgell, D. R., Landthaler, M. and Shub, D. A. 2001. Intron Homing. eLS. .

Author Information

  1. State University of New York at Albany, New York, USA

Publication History

  1. Published Online: 19 APR 2001


Introns belonging to the group I or group II self-splicing types are mobile elements that can move into unoccupied sites in homologous genes (homing), or into new genomic sites (transposition). This mobility is mediated by intron-encoded proteins: site-specific endonucleases in the case of group I introns and chimaeric proteins containing reverse transcriptase activity for group II introns.


  • double-strand break repair;
  • reverse splicing;
  • site-specific DNA endonuclease;
  • transposition;
  • reverse transcription