Standard Article

Introns: Group I Structure and Function

  1. Bruno Paquin1,
  2. David A Shub2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000884



How to Cite

Paquin, B. and Shub, D. A. 2001. Introns: Group I Structure and Function. eLS. .

Author Information

  1. 1

    University of Montreal, Montreal, Canada

  2. 2

    State University of New York at Albany, New York, USA

Publication History

  1. Published Online: 19 APR 2001


Group I introns fold into characteristic secondary and tertiary structures. In a Mg2+-dependent reaction initiated by a guanosine cofactor, group I ribozymes catalyse their own excision from the primary transcript. In addition, group I introns often contain an open reading frame that assists the intron in its own mobility.


  • RNA structure;
  • self-splicing;
  • ribozyme;
  • mobile genetic elements