Standard Article

Kallikrein–Kinin System

  1. Domenico Regoli1,
  2. Girolamo Calo1,
  3. Fernand Gobeil2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0000905



How to Cite

Regoli, D., Calo, G. and Gobeil, F. 2001. Kallikrein–Kinin System. eLS. .

Author Information

  1. 1

    University of Ferrara, Ferrara, Italy

  2. 2

    University of Sherbrooke, Quebec, Canada

Publication History

  1. Published Online: 19 APR 2001


Two similar proteolytic cascades lead to release of bradykinin and lysbradykinin in tissues; these peptides act as autocoids, the first favouring blood clotting and endothelial protection, the second by initiating and maintaining tissue reactions to noxious stimuli. Kinin biological actions are mediated by two different receptor types, the constitutive B2 which promotes initial reactions and the inducible B1 which may later maintain mechanisms of defence and repair.


  • kallikreins;
  • kinins;
  • B1 and B2 receptors