Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Natarajan, K., Mage, M. G. and Margulies, D. H. 2006. Immunoglobulin Superfamily. eLS. .
- Published Online: 27 JAN 2006
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The immunoglobulin superfamily (IgSF) consists of a group of proteins that exploit the structural robustness and fundamental stability of the immunoglobulin fold for a wide assortment of functions across a broad span of evolutionary time, extending from microorganisms to humans. Although the best understood activities of IgSF members are related to immunological recognition, a number of related molecules participate in developmental and homeostatic phenomena. Manipulation of the IgSF by recombinant gene technology offers in vitro approaches to increase the available diversity of novel structures for almost limitless functions.
- molecular fold;
- structural motif;
- T-cell receptors;
- immune recognition