Published Online: 16 MAY 2002
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Kushner, S. R. 2002. Nucleases. eLS. .
- Published Online: 16 MAY 2002
While the genetic information encoded in DNA and RNA molecules is directly related to the order of the purine and pyrimidine bases, it is the sugar–phosphate backbone that provides the glue that keeps these molecules intact. It is the function of nucleases to break the stable phosphodiester bonds between the sugar moieties when necessary. Nucleases participate in almost all biological reactions involving either RNA or DNA.
- DNA metabolism;
- RNA metabolism;
- phosphodiester bond cleavage;