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DNA Topology: Fundamentals

  1. Sergei M Mirkin

Published Online: 30 MAY 2001

DOI: 10.1038/npg.els.0001038

eLS

eLS

How to Cite

Mirkin, S. M. 2001. DNA Topology: Fundamentals. eLS. .

Author Information

  1. University of Illinois at Chicago, Illinois, USA

Publication History

  1. Published Online: 30 MAY 2001

Abstract

Topological characteristics of DNA and specifically DNA supercoiling influence all major DNA transactions in living cells. DNA supercoiling induces the formation of unusual secondary structure by specific DNA repeats which can also affect DNA functioning.

Keywords:

  • supercoiling;
  • knots;
  • catenanes;
  • Z-DNA;
  • triplexes;
  • cruciforms