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Topoisomerases

  1. Andrew D Bates

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001039

eLS

eLS

How to Cite

Bates, A. D. 2001. Topoisomerases. eLS. .

Author Information

  1. University of Liverpool, Liverpool, UK

Publication History

  1. Published Online: 19 APR 2001

Abstract

Topoisomerases are enzymes that interconvert different topological states of DNA, such as levels of supercoiling, catenanes (links) and knots. They are vital to all DNA-related processes and are the targets for a number of antibacterial and anticancer agents.

Keywords:

  • DNA topology;
  • gyrase;
  • replication;
  • anticancer agents;
  • antibacterials