Standard Article

Polymerase Processivity: Measurement and Mechanisms

  1. Linda B Bloom1,
  2. Myron F Goodman2

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001052

eLS

eLS

How to Cite

Bloom, L. B. and Goodman, M. F. 2001. Polymerase Processivity: Measurement and Mechanisms. eLS. .

Author Information

  1. 1

    Arizona State University, Tempe, Arizona, USA

  2. 2

    University of Southern California, Los Angeles, California, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

The processivity of DNA synthesis by a DNA polymerase is defined as the number of nucleotides that a polymerase can incorporate into DNA during a single template-binding event, before dissociating from a DNA template. The overall efficiency of DNA synthesis increases when the processivity of a polymerase increases.

Keywords:

  • DNA polymerase;
  • DNA replication;
  • processivity;
  • polymerase accessory proteins