Standard Article

DNA Polymerase Fidelity Mechanisms

  1. Deborah Kuchnir Fygenson,
  2. Myron F Goodman

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001053



How to Cite

Fygenson, D. K. and Goodman, M. F. 2001. DNA Polymerase Fidelity Mechanisms. eLS. .

Author Information

  1. University of Southern California, Los Angeles, California, USA

Publication History

  1. Published Online: 19 APR 2001


DNA polymerase is a protein that catalyses the polymerization of one strand of DNA, called the primer strand, based on the sequence in another strand, called the template strand. Fidelity in this process refers to the ability of the polymerase to avoid or to correct errors in the newly synthesized strand.


  • mutation;
  • proofreading;
  • exonuclease;
  • processivity proteins;
  • SOS response