Standard Article

DNA Ligases

  1. Stewart Shuman1,
  2. Richard I Gumport2

Published Online: 22 JAN 2002

DOI: 10.1038/npg.els.0001057



How to Cite

Shuman, S. and Gumport, R. I. 2002. DNA Ligases. eLS. .

Author Information

  1. 1

    Sloan-Kettering Memorial Cancer Research Center, New York, USA

  2. 2

    University of Illinois, Urbana, Illinois, USA

Publication History

  1. Published Online: 22 JAN 2002


DNA ligases are essential enzymes that catalyse the formation of a phosphodiester bond at a discontinuity in the deoxyribose phosphate backbone of duplex DNA.


  • DNA ligase;
  • polynucleotide ligase;
  • RNA capping enzymes;
  • phosphodiester bond formation;
  • NAD+;
  • NMN;
  • ATP;
  • DNA;
  • nicked