Standard Article

Site-specific Recombination

  1. Anca Segall

Published Online: 30 MAY 2001

DOI: 10.1038/npg.els.0001058



How to Cite

Segall, A. 2001. Site-specific Recombination. eLS. .

Author Information

  1. San Diego State University, San Diego, California, USA

Publication History

  1. Published Online: 30 MAY 2001


Site-specific recombination is defined as the rearrangement of two DNA partner molecules by specific enzymes performing recombination at their cognate pairs of sequences or target sites. Site-specific recombination, in contrast to homologous recombination, requires very little DNA homology between partner DNA molecules, is RecA-independent, and does not involve DNA replication at any stage.


  • integrase;
  • resolvase;
  • invertase;
  • gene expression;
  • chromosome segregation;
  • lysogeny;
  • gene targeting