Standard Article

Integrase Class Site-specific Recombinases

  1. John J Scocca

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001059

eLS

eLS

How to Cite

Scocca, J. J. 2001. Integrase Class Site-specific Recombinases. eLS. .

Author Information

  1. The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

The integrase family of recombination proteins promote coordinated conservative DNA breakage–rejoining reactions at duplex DNA sites of defined sequence. They ensure accurate partition of duplicated circular prokaryotic chromosomes or insert and remove temperate phage genomes from host chromosomes through formation of a DNA–integrase phosphodiester linkage between a tyrosyl residue and a 3′-phosphoryl group.

Keywords:

  • tyrosine recombinases;
  • mobile genetic elements;
  • bacteriophage;
  • covalent catalysis;
  • topoisomerases