Integrase Class Site-specific Recombinases
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Scocca, J. J. 2001. Integrase Class Site-specific Recombinases. eLS. .
- Published Online: 19 APR 2001
The integrase family of recombination proteins promote coordinated conservative DNA breakage–rejoining reactions at duplex DNA sites of defined sequence. They ensure accurate partition of duplicated circular prokaryotic chromosomes or insert and remove temperate phage genomes from host chromosomes through formation of a DNA–integrase phosphodiester linkage between a tyrosyl residue and a 3′-phosphoryl group.
- tyrosine recombinases;
- mobile genetic elements;
- covalent catalysis;