Standard Article

Affinity of Antigen–Antibody Interactions

  1. David Goldblatt

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0001113



How to Cite

Goldblatt, D. 2001. Affinity of Antigen–Antibody Interactions. eLS. .

Author Information

  1. Institute of Child Health, University College London, UK

Publication History

  1. Published Online: 25 APR 2001


Antibody affinity is the strength with which antibody binds to its target antigen. It is influenced by a variety of factors including valency and the precise fit of the antigen in the antigen binding groove. Antibody affinity increases over time following contact or repeated immunization with certain types of antigen. The affinity of an antibody may have an influence on its function.


  • antibody;
  • affinity;
  • avidity;
  • memory;
  • somatic mutation