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Nucleosomes: Structure and Function

  1. Karolin Luger

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0001155

eLS

eLS

How to Cite

Luger, K. 2001. Nucleosomes: Structure and Function. eLS. .

Author Information

  1. Colorado State University, Fort Collins, Colorado, USA

Publication History

  1. Published Online: 25 APR 2001

Abstract

The structure of the nucleosome core particle, the basic repeating unit in eukaryotic chromatin, allows us to view the role of histones in regulating transcription, and in assembling specialized chromatin domains in a structural context. The organization of eukaryotic DNA into chromatin has fundamental implications for our understanding of all cellular processes that use DNA as a substrate.

Keywords:

  • histone;
  • nucleosome;
  • chromatin;
  • DNA;
  • crystal structure;
  • transcription regulation