Standard Article

Nucleosomes: Detailed Structure and Mutations

  1. Alan P Wolffe

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0001156

eLS

eLS

How to Cite

Wolffe, A. P. 2001. Nucleosomes: Detailed Structure and Mutations. eLS. .

Author Information

  1. National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 25 APR 2001

Abstract

The nucleosome is the fundamental repeating unit of chromatin that provides a structural and regulatory infrastructure for chromosomal DNA. Transcription, replication, recombination and repair of eukaryotic chromosomes all make very effective use of the nucleosomal infrastructure to fulfil mechanistic and regulatory requirements.

Keywords:

  • histones;
  • transcriptional regulation;
  • acetyltransferases and deacetylases;
  • DNA structure;
  • chromatin and chromosomes