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Nucleosomes: Detailed Structure and Mutations

  1. Alan P Wolffe

Published Online: 25 APR 2001

DOI: 10.1038/npg.els.0001156



How to Cite

Wolffe, A. P. 2001. Nucleosomes: Detailed Structure and Mutations. eLS. .

Author Information

  1. National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 25 APR 2001


The nucleosome is the fundamental repeating unit of chromatin that provides a structural and regulatory infrastructure for chromosomal DNA. Transcription, replication, recombination and repair of eukaryotic chromosomes all make very effective use of the nucleosomal infrastructure to fulfil mechanistic and regulatory requirements.


  • histones;
  • transcriptional regulation;
  • acetyltransferases and deacetylases;
  • DNA structure;
  • chromatin and chromosomes