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Chromosomes: Nonhistone Proteins

  1. Katalin A Holland

Published Online: 28 MAY 2003

DOI: 10.1038/npg.els.0001158



How to Cite

Holland, K. A. 2003. Chromosomes: Nonhistone Proteins. eLS. .

Author Information

  1. University of London, London, UK

Publication History

  1. Published Online: 28 MAY 2003


Chromatin is a dynamic structure alternating between condensed and decondensed states, depending on the stage of the cell cycle. Nonhistone proteins play essential roles in both states, including higher-order chromosome organization, differential chromosome packaging and local chromatin architecture.


  • scaffold;
  • SMC;
  • metaphase–anaphase switch;
  • gene silencing;
  • architectural transcription factor