Standard Article

Artificial Chromosomes

  1. Gert Roosen,
  2. Florian W Velten,
  3. Jean-Michel H Vos†

Published Online: 22 MAR 2002

DOI: 10.1038/npg.els.0001159



How to Cite

Roosen, G., Velten, F. W. and Vos†, J.-M. H. 2002. Artificial Chromosomes. eLS. .

Author Information

  1. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Publication History

  1. Published Online: 22 MAR 2002


Artificial chromosomes are DNA molecules assembled in vitro from defined constituents, which guarantee stable maintenance of large DNA fragments with the properties of natural chromosomes. Artificial chromosomes are useful for genome sequencing programmes, for functional characterization of entire genomic regions and for the transduction of large DNA segments into human and nonhuman mammalian cells.


  • BAC;
  • YAC;
  • PAC;
  • MAC;
  • Epstein-Barr virus