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Immunoglobulin Gene Construction: Human

  1. Alexander H Lucas

Published Online: 28 MAY 2003

DOI: 10.1038/npg.els.0001172



How to Cite

Lucas, A. H. 2003. Immunoglobulin Gene Construction: Human. eLS. .

Author Information

  1. Children's Hospital Oakland Research Institute, Oakland, California, USA

Publication History

  1. Published Online: 28 MAY 2003


Human immunoglobulin genes exist as tandem arrays of gene segments that undergo somatic recombination and hypermutation during B-lymphocyte development. Together, these processes enable the generation of a vast repertoire of immunoglobulin molecules capable of recognizing and eliminating infectious agents.


  • antibody;
  • immunoglobulin;
  • variable region;
  • constant region;
  • somatic recombination;
  • hypermutation