Standard Article

You have free access to this content

Mechanisms of X-inactivation

  1. Sarah M Duthie

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001194



How to Cite

Duthie, S. M. 2001. Mechanisms of X-inactivation. eLS. .

Author Information

  1. Medical Research Council Clinical Sciences Centre, London, UK

Publication History

  1. Published Online: 19 APR 2001


X-inactivation involves the transcriptional silencing of one of the two X-chromosomes in the cells of female mammals. This process is controlled by elements present in the X-inactivation centre (Xic) which is required in cis for X-inactivation to occur.


  • xist;
  • X chromosome inactivation;
  • dosage compensation;
  • chromatin;
  • X inactivation centre