Published Online: 25 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Bershadsky, A. D. and Elbaum, M. 2001. Cell Locomotion. eLS. .
- Published Online: 25 APR 2001
The crawling locomotion of animal cells results from a coordinated cycle of protrusion, attachment and retraction. Protrusions in the direction of motion are normally generated by controlled assembly of actin networks, while adhesion and retraction rely as well on tension generated by actin–myosin interactions. Microtubules control the spatial distribution of these activities, creating a polarized shape in the cell that determines the direction of motion. All these processes are coordinated by small G proteins of the Rho family.
- G proteins