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Protein–Ligand Interactions: Energetic Contributions and Shape Complementarity

  1. Chung-Jung Tsai1,
  2. Raquel Norel2,
  3. Haim J Wolfson2,
  4. Jacob V Maizel1,
  5. Ruth Nussinov1

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001343

eLS

eLS

How to Cite

Tsai, C.-J., Norel, R., Wolfson, H. J., Maizel, J. V. and Nussinov, R. 2001. Protein–Ligand Interactions: Energetic Contributions and Shape Complementarity. eLS. .

Author Information

  1. 1

    Frederick Cancer Research and Development Center, Frederick, Maryland, USA

  2. 2

    Tel Aviv University, Tel Aviv, Israel

Publication History

  1. Published Online: 19 APR 2001

Abstract

Protein–ligand interactions include two components: energetic contributions and shape complementarity.

Keywords:

  • hydrophobic effect;
  • hydrogen bonds;
  • shape complementarity;
  • molecular recognition;
  • receptor–ligand interactions