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Checkpoints in the Cell Cycle

  1. Béla Novák1,
  2. Jill C Sible2,
  3. John J Tyson2

Published Online: 26 FEB 2003

DOI: 10.1038/npg.els.0001355



How to Cite

Novák, B., Sible, J. C. and Tyson, J. J. 2003. Checkpoints in the Cell Cycle. eLS. .

Author Information

  1. 1

    Budapest University of Technology and Economics, Budapest, Hungary

  2. 2

    Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

Publication History

  1. Published Online: 26 FEB 2003


Surveillance mechanisms stop progression through the cell cycle at specific checkpoints (at the G1 [RIGHTWARDS ARROW] S, G2 [RIGHTWARDS ARROW] M and metaphase [RIGHTWARDS ARROW] anaphase transitions) if certain crucial requirements have not been met. These checkpoint controls are essential for maintaining genomic integrity and balanced growth and division.


  • G1 checkpoint;
  • G2 checkpoint;
  • spindle checkpoint;
  • restriction point;
  • Start