Standard Article

Mitosis

  1. Erich A Nigg

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001356

eLS

eLS

How to Cite

Nigg, E. A. 2001. Mitosis. eLS. .

Author Information

  1. Max Planck Institute for Biochemistry, Martinsried, Germany

Publication History

  1. Published Online: 19 APR 2001

This is not the most recent version of the article. View current version (15 JUL 2015)

Abstract

Mitosis is the creation of genetically identical cells from a single parental cell, involving the segregation of chromosomes to daughter cells, via a microtubule-based structure known as the mitotic spindle. Cells first undergo nuclear division, followed by cytoplasmic division (cytokinesis). Missing or extra chromosomes (aneuploidies) can cause miscarriages, birth defects and malignant tumours.

Keywords:

  • chromosome segregation;
  • microtubule-based spindle;
  • cytokinesis;
  • centrosome;
  • cyclin-dependent kinase;
  • phosphorylation;
  • proteolysis