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  1. Erich A Nigg

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001356



How to Cite

Nigg, E. A. 2001. Mitosis. eLS. .

Author Information

  1. Max Planck Institute for Biochemistry, Martinsried, Germany

Publication History

  1. Published Online: 19 APR 2001

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Mitosis is the creation of genetically identical cells from a single parental cell, involving the segregation of chromosomes to daughter cells, via a microtubule-based structure known as the mitotic spindle. Cells first undergo nuclear division, followed by cytoplasmic division (cytokinesis). Missing or extra chromosomes (aneuploidies) can cause miscarriages, birth defects and malignant tumours.


  • chromosome segregation;
  • microtubule-based spindle;
  • cytokinesis;
  • centrosome;
  • cyclin-dependent kinase;
  • phosphorylation;
  • proteolysis