Blood Clotting: General Pathway
Published Online: 19 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Berkner, K. L. 2001. Blood Clotting: General Pathway. eLS. .
- Published Online: 19 APR 2001
Haemostasis is the process that maintains blood in a fluid state while retaining the capacity to respond to injury by forming a clot to stem blood loss. This process comprises a complex interplay between circulating and cellular proteins which regulate the formation of fibrin and the fibrin/platelet haemostatic plug at the site of injury, and defects in the individual proteins can lead to bleeding disorders (haemophilia). Several of the proteins that participate in haemostasis require vitamin K for function, and inhibition of vitamin K action is commonly used in anticoagulant therapy.
- vitamin K;
- clotting factors