Standard Article

Blood Clotting: General Pathway

  1. Kathleen L Berkner

Published Online: 19 APR 2001

DOI: 10.1038/npg.els.0001408

eLS

eLS

How to Cite

Berkner, K. L. 2001. Blood Clotting: General Pathway. eLS. .

Author Information

  1. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Publication History

  1. Published Online: 19 APR 2001

Abstract

Haemostasis is the process that maintains blood in a fluid state while retaining the capacity to respond to injury by forming a clot to stem blood loss. This process comprises a complex interplay between circulating and cellular proteins which regulate the formation of fibrin and the fibrin/platelet haemostatic plug at the site of injury, and defects in the individual proteins can lead to bleeding disorders (haemophilia). Several of the proteins that participate in haemostasis require vitamin K for function, and inhibition of vitamin K action is commonly used in anticoagulant therapy.

Keywords:

  • haemostasis;
  • coagulation;
  • vitamin K;
  • haemophilia;
  • clotting factors