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Immune Deficiency: Severe Combined Immune Deficiency

  1. Jintanat Ananworanich,
  2. William T Shearer

Published Online: 29 JAN 2003

DOI: 10.1038/npg.els.0001458

eLS

eLS

How to Cite

Ananworanich, J. and Shearer, W. T. 2003. Immune Deficiency: Severe Combined Immune Deficiency. eLS. .

Author Information

  1. Baylor College of Medicine, Houston, Texas, USA

Publication History

  1. Published Online: 29 JAN 2003

Abstract

Severe combined immune deficiency (SCID) represents a diverse group of disorders caused by genetic defects in T-cell development and signalling pathways, the most common being the mutation of the interleukin-2 receptor γ chain leading to X-linked SCID.

Keywords:

  • T cell;
  • bubble boy;
  • combined immune deficiency (CID);
  • severe combined immune deficiency (SCID);
  • stem cell transplantation